'Major setback' for the touring side as Atkinson is forced off suffering a hamstring problem.
The pace bowler added to the injury concerns plaguing England after leaving the playing area on the second morning of the Boxing Day Test versus the Australians.
Atkinson experienced discomfort in his hamstring post-delivery of the fourth over during the morning session.
The touring camp indicated Atkinson felt some "soreness" and would spend time off the field for further assessment "over the next few hours".
The concluding match of the tour in Sydney gets underway this coming Sunday.
The visitors have previously lost fast bowlers one seamer with a knee problem and Jofra Archer with an abdominal strain during this series.
A replacement bowler was added to the party to provide backup.
His form was underwhelming early in the series, managing only a handful of scalps.
He was left out for the Adelaide match, only to be brought back for the Melbourne Test to fill the void.
Atkinson improved at the MCG, taking two wickets with the ball, then making 28 while batting among just a trio of England players to reach double figures.
After bowling one over at the end of day one, he returned for the second day's play and removed Scott Boland edging to the keeper.
However, at the end of the fifth over, he bowled a change of pace to the batsman and suddenly grabbed his left hamstring.
Atkinson was recalled for the fourth Ashes Test having missed of the third.
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